Charlie Gard, the baby at the centre of a legal row over his treatment, has died, a family spokesman has confirmed.
The 11-month-old was moved to a hospice following a High Court ruling.
He suffered from an extremely rare genetic condition causing progressive brain damage and muscle weakness.
His parents, Connie Yates and Chris Gard, fought a lengthy legal battle with Great Ormond Street Hospital (GOSH) to allow him to be taken to the US for treatment.
But on Monday they dropped their legal battle after Prof Michio Hirano, the American neurologist who had offered to treat him, said it was too late for it to work.
In a statement issued on Friday evening, Ms Yates said: “Our beautiful little boy has gone, we are so proud of you Charlie.”
Prime Minister Theresa May said: “I am deeply saddened by the death of Charlie Gard. My thoughts and prayers are with Charlie’s parents Chris and Connie at this difficult time.”
Pope Francis tweeted: “I entrust little Charlie to the Father and pray for his parents and all those who loved him.”