Toxic ‘Forever Chemicals’ accumulate in testes

The Guardian
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New research has found for the first time that PFAS “forever chemicals” accumulate in the testes, and the exposure probably affects children’s health.

The toxic chemicals can damage sperm during a sensitive developmental period, potentially leading to liver disease and higher cholesterol, especially in male offspring, the paper, which looked at the chemicals in mice, noted.

The research is part of a growing body of work that highlights how paternal exposure to toxic chemicals “can really impact the health, development and future diseases of the next generation”, said Richard Pilsner, a Wayne State University School of Medicine researcher who co-authored the study.

“We’ve always been concerned with maternal environmental health effects because women gestate the babies … but this research is really saying there is a paternal contribution to offspring health and development,” Pilsner added.

PFAS are a class of about 16,000 compounds used to make products resist water, stains and heat. They are called “forever chemicals” because they do not naturally break down and have been found to accumulate in humans. The chemicals are linked to cancer, birth defects, liver disease, thyroid disease, plummeting sperm counts and a range of other serious health problems.

PFAS alters sperm DNA methylation, which is a process that turns genes on and off, Pilsner said. The methylation patterns can be inherited at fertilization and influence early-life development as well as offspring health later in life.


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Chuck comes from a lineage of journalism. He has written for some of the webs most popular news sites. He enjoys spending time outdoors, bull riding, and collecting old vinyl records. Roll Tide!